Phase I Experience with Emetine Hydrochloride ( Nsc 33669 ) As
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چکیده
This report details a Phase I dose-ranging experiment of the use of emetine in patients with a variety of malignant diseases. The data show that emetine can be given intravenously a t 4-day intervals with minimal toxicity. Severe muscle weakness, the most important dose-limiting toxic effect, began a t approximately a 15 mg/kg cumulative dose level and resulted in discontinuance of therapy i n two patients. Of 5 patients who received greater than 10.4 mg/kg, 2 stabilized previously rapidly progressive disease, one had marked reduction in a purulent bloody vaginal discharge, a n d 2 who had received the highest total dose had 50% or greater reduction i n lung tumor size. T h e present data suggest a reasonable regimen t o be 1.5 mg/kg I V weekly for a minimum total dose of 15 nig/kg. Emetine is not myelosuppressive and therefore may be useful i n the patient with poor marrow reserve. Alternatively, i t can be used in combination with agents of different toxicities in hope of showing additive effects without additive toxicity.
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تاریخ انتشار 2006